CURC – Debbie Crans Research Group

The Crans group participates every year in the Celebrate Undergraduate Research and Creativity symposium held on campus every Spring. Undergraduates share their research in a poster session among all departments of the university. Please see www.http://curc.colostate.edu/ for more information.

CURC 2023

Nine Crans Group undergrads presented at CURC in 2023 with 5 undergrads winning awards. Congratulations to Rayley Patch, Andre Eberspacher, Anna Galaeva, Madelyna Le, Tyler Lewis, Ellie Nelson, Ella Kim, Lilli Rose and Drew Walters.

Division: College of Natural Science – Chemistry Poster Number and Title: 89 – Stability studies and spectroscopy characterization of Novel Vanadium Catechol Complexes Authors: André Eberspacher, Kateryna Kostenkova, Debbie C. Crans **Fourth Best in Show**

Division: College of Natural Science – Chemistry Poster Number and Title: 93 – Sterically Hindered Hydrophobic Vanadium(V) Complexes as Chemotherapeutics Authors: Anna Galaeva, Debbie C. Crans, John Manganaro **College Honors**

Division: College of Natural Science – Chemistry Poster Number and Title: 95 – Synthesis, Separation, and Characterization of Menaquinone and Demethylmenaquinone Derivatives Authors: Madelyna Le, Skylar Markham, Dr. Debbie Crans

Division: College of Natural Science – Chemistry Poster Number and Title: 77 – Synthesis, Characterization, and Stability of Novel Vanadium Catechol Complexes Authors: Tyler Lewis, Andrew Bates, Dr. Debbie Crans **High Honors**

Division: College of Natural Science – Chemistry Poster Number and Title: 221 – Synthesis and Characterization of SchiffBase Metal Catecholate Complexes for Intratumoral Cancer Treatment Authors: Ellie Nelson, Ella Kim, Dr. Debbie Crans, Skyler Markham **Highest Honors**

Division: College of Natural Science – Chemistry Poster Number and Title: 87 – Solution Characterization of Menaquinone Derivatives by using NMR Spectroscopy Authors: Raley Patch Dr. Debbie Crans

Division: College of Natural Science – Chemistry Written Work Number and Title: 90 – Neuroscience and Structures of Receptors related to Addiction: Introductory Text for Chem 320 Authors: Lilli Rose, Connor Dolan, Violet M. Farmer, Deborah A. Roess,
Debbie C. Crans

Division: College of Natural Science – Chemistry Written Work Number and Title: 88 – Redox Chemistry of Non-innocent Vanadium(V) Schiff Base SALIEP Catecholate Complexes Authors: Drew Walters, Kate Kostenkova, Debbie Crans

CURC 2017

Division: College of Veterinary Medicine and Biomedical Sciences – Neuroscience Poster Number and Title: 14 – Development of Metal Ion Release by Photo-induced Decarboxylation Cages to study Fast-time Scale Metal Chelation by Amyloids in a Single Solution Authors: Noah Barley, Cheryle Beuning, Nancy Levinger, Debbie Crans Winner of College Honor Award

Division: College of Natural Sciences – Biological Science Poster Number and Title: 33 – Investigating the Interactions Between the Anti-Tuberculosis Agent, Isoniazid, and Reverse Micelles Using 1D and 2D NMR spectroscopy Authors: Gabriel Cardiff, Benjamin Peters, Debbie Crans Winner of College Honor Award

Division: College of Natural Science – Biochemistry Poster Number and Poster Number: 85 – Preparation and Characterization of a Potential Anti-Diabetic Vanadium (V) Catecholate Complex and the Elucidation of its Interaction with A Reverse Micelle Model Membrane System Authors: Caleb Glover, Jordan Koehn, Debbie Crans

Division: College of Natural Sciences – Biochemistry Poster Number and Title: 91 – Interactions of Isoniazid with Model Membranes Authors: Allison Groninger, John Peter Hough, Benjamin Peters, Dean Crick, Debbie Crans

Division: College of Natural Sciences – Chemistry Poster Number and Title: 96 – Synthesis of a Novel Potental Anti-TB Agent: Isoiazidium Decavanadate Authors: Molly Hartman, Benjamin Peters, Debbie Crans

Division: College of Natural Sciences – Biochemistry Poster Number and Title: 101 – Creation of a Novel Liposomal Technique for Monitoring pH Collapse Across a Bilayer: Modeling the Mechanism of Action of the Anti-Tuberculosis Drug Pyrazinamide Authors: LaRee Henry, Kaitlin Doucette, Debbie Crans

Division: College of Natural Sciences – Biochemistry Poster Number and Title: 108 – Exploring the Interactions between the Anti-Tuberculosis Agent, Pyrazinamide/Pyrazonic Acid, and the Lipid Model Membrane Systems Authors: John Peter Hough, Benjamin Peters, Debbie Crans

Division: Walter Scott Jr. College of Engineering – Chemical Engineering Poster Number and Title: 175 – Synthesis of the Fully Reduced Substrate, Menaquinone-3 (H6) for the New Virulence Factor, MenJ, in Mycobacterium Tuberculosis Authors: Thomas Olson, Jordan Koehn, Debbie Crans

Division: College of Veterinary Medicine and Biomedical Sciences – Biomedical Sciences Poster Number and Title: 180 – Characterization of the Coordination Complex of Zinc (II) Ion with Zincon Authors: Laura Osborn, Luca Zocchi, Cheryle Beuning, Nancy Levinger, Debbie Crans

Division: College of Natural Sciences – Chemistry Poster Number and Title: 184 – Exploration of Inhomogeneous Hydrophobic Environments on Photolysis Reactions: Photolysis of Zn(II)-Nitrilotriacetate in AOT Reverse Micelles Authors: Twinkle Paryani, Noah Barkley, Cheryle Beuning, Debbie Crans

Division: College of Natural Sciences – Biochemistry Poster Number and Title: 189 – How the Drug Treating Diabetic Cataracts, Alrestatin, Interacts with Membrane Model Systems and How these Interactions May Affect the Drug’s Mode of Action Authors: Eric Pohlen, Kelly Hassell, Debbie Crans Winner of the Best in Show Award

Division: College of Natural Sciences – Biochemistry Poster Number and Title: 193 – Progress toward the Synthesis of the Partially Reduced Menaquinone-3 Lipid for Studies of Electron Transfer in Mycobacterium tuberculosis Authors: Madeline Pumm, Jordan Koehn, Debbie Crans Winner of High Honor Award

Division: Warner College of Natural Resources – Ecosystem Science and Sustainability Poster Number and Title: 119 – Soil Food Web Dynamics in Costa Rica Authors: Morgan Salter, Nathan Kendzior, John Moore

Division: College of Natural Sciences – Chemistry Poster Number and Title: 208 – The State of Science in the Division of Inorganic Chemistry in American Chemistry Society Authors: Morgan Salter, Debbie Crans

Division: College of Natural Sciences – Chemistry Poster Number and Title: 209 – Food Web Comparison of the Costa Rican Forests at La Silva Authors: Morgan Salter, John Moore

Division: College of Health and Human Sciences – Health and Exercise Science Poster Number and Title: 220 – Rethink Your Office Chair: Energy Expenditure When Sitting in a Regular Chair, on an Exercise Ball Chair, or Standing at a Desk Authors: Nicole Segaline, Robert Musci, Katherine Hutcheson, Barry Braun

Division: College of Health and Human Sciences – Health and Exercise Science Poster Number and Title: 221 – Weak Acid Passively Diffuse through Bulk Liquid Membrane System Authors: Nicole Segaline, Benjamin Peter, Debbie Crans

Division: College of Business – Business Poster Number and Title: 275 – Phospholipid Interactions with Menaquinone Homologues Using the Langmuir TroughAuthors: Katarina Werst, Benjamin Peters, Dean Crick, Debbie Crans

Division: College of Natural Sciences – Chemistry Poster Number and Title: 264 – Characterization of Menaquinone-3 (MK-3) Solution Structure and Interaction with a Model Membrane System Authors: Wenjie Yan, Jordan Koehn, Debbie Crans

Division: College of Veterinary Medicine and Biomedical Sciences – Biomedical Sciences Poster Number and Title: 180 – Characterization of the Coordination Complex of Zinc (II) Ion with Zincon Authors: Luca Zocchi, Laura Osborn, Cheryle Beuning, Nancy Levinger, Debbie Crans

CURC 2016

The annual Celebrate Undergraduate Research and Creativity (CURC) symposium took place on April 18, 2016, in which 14 undergraduates from the Crans group participated and 6 participants won awards. Congratulations to the winners and all CURC participants – you are all winners for what you accomplished!

Contributors:

Noah Barkley and Sumaiyah Mujtaba: “Exploring the complex of citrate with selenium”
David Dummer: “Evaluating photoacid viability for use in Cu2+-‐amyloid beta aggregation studies”
Caleb Glover: “Preparation and characterization of a potential anti-‐diabetic catecholate-‐Schiff base-‐vanadium complex”
Allison Groninger: “Benzoic acid effect on model membranes in relation to tuberculosis” and “Exploring the interactions between the anti tuberculosis agent, pyrazinoic acid, and lipid model membrane systems”
LaRee Henry and Winjie Yan: “Exploration of the stability of the Schiff base functionality during drug formulation”
John Peter Bartholomew Hough: “Exploring the interactions between the anti tuberculosis agent, pyrazinoic acid, and lipid model membrane systems”
Olivia Kinney: “Are some areas of general chemistry more important to successfully learning organic chemistry?”
Jackson McCue: “The interaction of HPTS and Cu2+ in reverse micelles”
TJ Olson: “MK Project: Study on column chromatography separation of menaquinones (MK)”
Nicole Segaline and Katarina Werst (a team project): “Modeling uncoupling affect of benzoic acid on Mycobacterium tuberculosis”
Xaio Wu: “Multinuclear NMR studies of aqueous vanadium-‐HEDTA complexes”

Awards Went To:

Allison Groninger: College Honors
John Peter Bartholomew Hough: College Honors
Jackson McCue: College Honors
Nicole Segaline: Highest Honors
Katarina Werst: Highest Honors

Top Right: Winners with Graduate Student Mentors. Jackson McCue (far left), Estella Magallenas, Katarina Werst, Nicole Segaline, Benjamin Peters (far right) Top Left: John Peter Bartholomew Hough receiving CURC award certificate from Alan Rudolph (Vice President for Research at CSU) Lower Left : Nicole Segaline receiving CURC award certificate from Alan Rudolph Lower Right : Katarina Werst receiving CURC award certificate from Alan Rudolph

2015 CURC Contributors

Sara Dellinger and Taylor Lucia : Authors Sara K. Dellinger, Jordan T. Koehn, Taylor Lucia, Ashutosh Upadhyay, Dean Crick, and Debbie C. Crans “Exploring the properties of several Vitamin K analogs and their potential as substrates for the newly discovered Mycobacterial tuberculosis enzyme”
Steve Glade: Authors: Steven Glade, Irma Sánchez Lombardo and Debbie C. Crans “Synthesis and Characterization of Oxovanadium Complexes Containing Anti-oxidant stressor Ligands for Anti-Parasitic Application”
Caleb Glover : Authors: Caleb Glover “Elucidating the Membrane Interactions of Metformin using Membrane Model Systems”
Allison Groninger : Authors: Allison J. Groninger, Benjamin J. Peters, Dean C. Crick and Debbie C. Crans “How Tuberculosis Drug Analog, Benzoic Acid, Interacts with Model Membranes”
Taylor Lucia : Authors: Taylor Lucia, Jordan Koehn, Pabitra B. Chatteriee, Andrew R. Waterhouse, Tatyana Polenova PhD, Michael D. Johnson PhD, and Debbie C. Crans “Correlation of redox potential with ⁵¹V NMR chemical shifts of Vanadium(V) Catecholates”
Jackson McCue: Authors: Jackson McCue, Ben Peters, Zeyad Arhouma, Debbie Crans and Dean Crick “The interaction of tuberculosis drugs and the nicotinamide analog with model membrane systems”
Nicholas McGlashen: Authors: Nicholas McGlashen, Jordan Koehn and Debbie Crans “Hypoglycemic Effects of Biguanice-Vanadyl Complexes”
Susannah Miller: Authors: Susannah Miller, Jarukorn Sripradite, Michael Johnson and Debbie Crans “Changing Acidity of Protonated Aniline near Oil-Water Interfaces”
Katarina Werst and Nicole Segaline (a team project): Authors: Katarina R. Werst, Nicole A. Segaline, Irma Sánchez-Lombardo, and Debbie C. Crans “Does asymmetry make a difference in membrane interactions of large vanadium insulin enhancing compounds?”
Xiao (Sherry) Wu: Authors: Xiao Wu, Ben Peters, Mary Fisher and Debbie Crans “Characterization of Vanadium-HEDT Complexes”

Awards went to:

CurcWinners

Steve Glade – Highest Honors, Susannah Miller – High Honors , Taylor Lucia – High Honors , Sara Dellinger and Taylor Lucia – High Honors, Nicholas Glashen – College Honors, Katarina Werst and Nicole Segaline – College Honors

The undergraduates and the graduate student mentors in the Crans group celebrated the hard work leading to CURC and the end of the semester by a potluck at Horsetooth Reservoir on Mary 3rd. The CURC participation from the group was at a record high (10 posters) and there were a record number of awards resulting (7 CURC awards). This semesters hard work will result in several of the students will be coauthors on papers some that we will be preparing for publication this summer